RONAI LAB

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

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    Enter Ronai Lab

    Poster illustrating colourful organic elements over black background.
    Poster illustrating colourful organic elements over black background.
    Poster illustrating a turtle winning a race againt a rabbit.
    The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The ability of ATF2 to reach the mitochondria is determined by PKCε, which directs ATF2 nuclear localization. Genotoxic stress attenuates PKCε effect on ATF2; enables ATF2 nuclear export and localization at the mitochondria, where it perturbs the HK1-VDAC1 complex; increases mitochondrial permeability; and promotes apoptosis. Significantly, high levels of PKCε, as seen in melanoma cells, block ATF2 nuclear export and function at the mitochondria, thereby attenuating apoptosis following exposure to genotoxic stress. In melanoma tumor samples, high PKCε levels associate with poor prognosis. Overall, our findings provide the framework for understanding how subcellular localization enables ATF2 oncogenic or tumor suppressor functions. Read more (Cell, 2012)
    Poster illustrating a compass-style gage with the tips pointing on "Metastasis" and "Proliferation".
    Poster illustrating Chinese fire crackers getting lit by match.
    Poster illustrating red cells in two separate flows run through a blue ring and redistribute.
    Poster illustrating magician tapping hat with an RNF5 wand. Colourful organic shapes flow out of the hat.
    Poster illustrating a woman sitting on the floor next to an unlocked vintage box. colourful light comes ot of the box saying S100A8. The lock reads: RNF5
    Poster illustrating a human heart with graphic diagrams over it.
    Transcriptionally inactive ATF2 (spliced form) functions as super oncogene, drives melanoma development only in the presence of BRAF mutant.
    Poster illustrating fighter jets spreading fire over fields
    Poster Illustrating a happy man breaking a chain attaching his leg to a metal ball with the word Melanoma on it.
    Poster illustrating a Pacman game over a digital map.
    Poster illustrating a ven diagram with 3 circles saying: Molecular profiling, Computational algorithm and Functional drug testing, with a man's silhouette in the middle.
    Poster illustrating Tucan birds flying over a rain forest picking Chameleons off of tree branches while flying by.
    Poster illustrating colourful organic elements over black background.
    Poster illustrating colourful organic elements over black background.
    Poster illustrating a turtle winning a race againt a rabbit.
    The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The ability of ATF2 to reach the mitochondria is determined by PKCε, which directs ATF2 nuclear localization. Genotoxic stress attenuates PKCε effect on ATF2; enables ATF2 nuclear export and localization at the mitochondria, where it perturbs the HK1-VDAC1 complex; increases mitochondrial permeability; and promotes apoptosis. Significantly, high levels of PKCε, as seen in melanoma cells, block ATF2 nuclear export and function at the mitochondria, thereby attenuating apoptosis following exposure to genotoxic stress. In melanoma tumor samples, high PKCε levels associate with poor prognosis. Overall, our findings provide the framework for understanding how subcellular localization enables ATF2 oncogenic or tumor suppressor functions. Read more (Cell, 2012)
    Poster illustrating a compass-style gage with the tips pointing on "Metastasis" and "Proliferation".
    Poster illustrating Chinese fire crackers getting lit by match.
    Poster illustrating red cells in two separate flows run through a blue ring and redistribute.
    Poster illustrating magician tapping hat with an RNF5 wand. Colourful organic shapes flow out of the hat.
    Poster illustrating a woman sitting on the floor next to an unlocked vintage box. colourful light comes ot of the box saying S100A8. The lock reads: RNF5
    Poster illustrating a human heart with graphic diagrams over it.
    Transcriptionally inactive ATF2 (spliced form) functions as super oncogene, drives melanoma development only in the presence of BRAF mutant.
    Poster illustrating fighter jets spreading fire over fields
    Poster Illustrating a happy man breaking a chain attaching his leg to a metal ball with the word Melanoma on it.
    Poster illustrating a Pacman game over a digital map.
    Poster illustrating a ven diagram with 3 circles saying: Molecular profiling, Computational algorithm and Functional drug testing, with a man's silhouette in the middle.
    Poster illustrating Tucan birds flying over a rain forest picking Chameleons off of tree branches while flying by.
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