We study signaling networks that are often deregulated in cancer, in an effort to understand why they are deregulated, and how it may be possible to correct them.
Most of our projects concern cellular stress signaling pathways, from ER stress, hypoxia, and cellular response to external (radiation and chemotherapy) and internal (reactive oxygen species) stress.
Among key pathways we focus on are ubiquitin ligases and stress activated kinases and their respective substrates. These players affect ER stress, cellular hypoxia, autophagy, and mitochondrial dynamics & biogenesis.
We use melanoma, prostate and breast cancer cell cultures, genetic models (GEM) and patient samples to validate our findings and develop potential new therapeutic modalities.
Our studies are funded by the National Cancer Institute, Melanoma Research Foundation (MRF), Melanoma Research Alliance, DoD, and The Hervey Family Non-endowment Fund at The San Diego Foundation.